Products
Our GPCR fluorescent ligands are the ideal solution for your High Throughput Screening (HTS) needs.
Our proprietary technology enables the synthesis of fluorescent ligands with exceptional performance features, including high potency, selectivity, and affinity. Our ligands have been designed to fill the gaps in the available tools for HTS, making the screening process faster and more efficient than ever before.
This technology has been used to study a variety of signaling pathways in drug discovery, providing an invaluable resource for researchers interested in GPCR signaling and drug discovery.
- Our ligands have a potent (Ki < 100 nM) and subtype-selective (>100-fold) feature that allows for thousands of tests in HTS assays, typically 3,000-6,000 points in 384 plates for a 10µg vial. The stable fluorophores, implemented to guarantee high affinity binding, present a variety of photo-physical properties adaptable for many different applications as Fluorescence Polarization and FRET.
- The pharmacophores of our ligands are representative of the target and are aligned with international standards, providing a reliable resource for researchers interested in G-protein-coupled receptor (GPCR) research and ligand binding. Our spacers allow optimal target recognition and placement of the fluorophore in the outer region of the cell membrane, enhancing the accuracy of the screening process.
At Celtarys, we are committed to providing you with the best products on the market for GPCR research and drug discovery, and we are constantly developing new solutions to meet your needs.
Published articles using our fluorescent probes
CELT-228 hA3 Adenosine receptor fluorescent antagonist (560/671)
CELT-335 hCB1/CB2 Cannabinoids receptors fluorescent ligand (646/662)
CELT-327 hA2B/A3 Adenosine receptor fluorescent antagonist (589/616)
LUXendin 551 glucagon-like peptide-1 receptor (GLP1R) fluorescent antagonist (551/576) (CELT-111)
LUXendin 645 glucagon-like peptide-1 receptor (GLP1R) fluorescent antagonist (645/664) (CELT-112)
LUXendin 762 glucagon-like peptide-1 receptor (GLP1R) fluorescent antagonist (762/784) (CELT-113)
CELT-419 hD3 Dopamine receptor fluorescent ligand (560/571)
CELT-483 hσ1/σ2 receptor fluorescent ligand (646/662)
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Showing 1–15 of 34 results
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CELT- 145 hAT1 angiotensin receptor fluorescent antagonist (646/662)
10ug vial that allows to prepare 63ml of 100nM working solution to test AT1 Receptor.
432,00€
Working concentration might differ among assay designsView moreOur CELT-145 ligand is a highly potent fluorescent antagonist developed for hA1R testing with a Ki of 160 nM in radioligand binding assay. The product comes in a 10ug vial that enables the preparation of 63ml of 100nM working solution to test AT1R. Our fluorescent antagonist is ideal for visualization in confocal microscopy and high-content system experiments. Our CELT-145 ligand is potentially suitable for other fluorescence-based assays such as HTRF.
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CELT- 252 hAT1 angiotensin receptor fluorescent antagonist (560/571)
10ug vial that allows to prepare 69ml of 100nM working solution to test AT1 Receptor.
432,00€
Working concentration might differ among assay designsView moreOur CELT-252 ligand is a highly potent fluorescent antagonist developed for hA1R testing with a Ki of 39 nM in radioligand binding assay. The product comes in a 10ug vial that enables the preparation of 69ml of 100nM working solution to test AT1R. Our fluorescent antagonist is ideal for visualization in confocal microscopy and high-content system experiments. Our CELT-252 ligand is potentially suitable for other fluorescence-based assays such as Fluorescence Polarization.
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CELT-150 VHL E3 ligase fluorescent ligand (646/662)
10ug vial that allows to prepare 33mL of 200 nM working solution.
250,00€
Working concentration might differ among assay designsView moreOur potent CELT-150 VHL E3 ligase fluorescent ligand is a tracer for VHL E3 ligases binding assays, designed to perform affinity binding curves to VHL protein using TR-FRET homogenous technology.
Von Hippel–Lindau protein (VHL) is the substrate recognition subunit of an E3 ligase recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a targeted protein.
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CELT-249 hM1/M2 Muscarinic Receptor fluorescent antagonist (589/616)
10ug vial that allows to prepare 82ml of 100nM working solution to test M1/M2 Muscarinic Receptor.
432,00€
Working concentration might differ among assay designsView moreOur CELT-249 ligand is a highly potent fluorescent antagonist developed for hM1R and hM2R testing with a Ki of 133 nM and 11.5 nM, respectively in radioligand binding assay. The product comes in a 10ug vial that enables the preparation of 82ml of 100nM working solution to test M1R/M2R. Our fluorescent antagonist is ideal for visualization in confocal microscopy and high-content system experiments. Our CELT-249 ligand is potentially suitable for other fluorescence-based assays
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CELT-483 Sigma hσ1/σ2 receptor fluorescent ligand (646/662)
10ug vial that allows to prepare 103 ml of 100nM working solution to test σ1/σ2 Receptors.
432,00€
Working concentration might differ among assay designsView moreOur potent Sigma h σ1/σ2 receptor fluorescent ligand is available in a 10ug vial, allowing you to prepare 103 ml of 100nM working solution to test σ1/σ2 receptors. Our CELT-483 product has been specifically designed to meet the needs of researchers in a variety of fields, enabling the study of σ1 and σ2 receptors with accuracy and precision. It has been validated in flow cytometry (Kd=13,59 nM for σ2) and confocal microcopy in MCF7 cell lines (see publication for more details) to study both σ1 and σ2 receptors, using the appropriate masking agent.
CELT-483 with masking agents kit
We also provide kits of CELT-483 together with potent and selective σ1 and σ2 receptors masking agents (L6 and F390, respectively).
490,00€
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CELT-501 – Oxytocin receptor fluorogenic agonist (597/657)
10ug vial that allows to prepare 55 ml of 100nM working solution to test oxytocin Receptor.
432,00€
Working concentration might differ among assay designsView moreOur potent hOT receptor fluorescent agonist shows high affinity for hOT receptor (Ki =0,54 nM in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy, high content system experiments and TR-FRET experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-502 – Oxytocin receptor fluorescent antagonist (650/667)
10ug vial that allows to prepare 79ml) of 100nM working solution to test oxytocin Receptor.
432,00€
Working concentration might differ among assay designsView moreOur potent and selective hOT receptor fluorescent antagonist shows high affinity for hOT receptor (Kd =1,59 nMin TR-FRET saturation binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy, high content system experiments and TR-FRET experiments. It is potentially suitable for other fluorescence-based assays.
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LUXendin551 GLP1 receptor (GLP1R) fluorescent antagonist (551/576) (CELT-111)
3nmoles vial that allows to prepare 30ml of 100nM working solution to test GLP1R. One vial is sufficient for injecting one mouse.
385,00€
Working concentration might differ among assay designs.View moreOur GLP1R fluorescent antagonist shows high affinity for GLP1 receptor (pIC50 = 7.2 for GLP1R) modulating the receptor by orthosteric antagonism.The efficacy and potency of LUXendin551 (CELT-111) as a GLP1R ligand was confirmed by inhibition of GLP-1-stimulated cAMP levels in SNAP-GLP1R:HEK293 cells. LUXendin551 (CELT-111) has been used in a variety of imaging applications, including widefield/confocal/2-photon microscopy in live and fixed mammalian cells and tissue, as well as anaesthetized mice.
*2º Image: Widefield image of live CHO-K1:SNAP-GLP1R cells labeled with 200 nM LUXendin551. Scale bar = 40 micrometer.
More information and applications
https://chemrxiv.org/engage/chemrxiv/article-details/60ff0d5a393cc904c94f1f18
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LUXendin645 GLP1 receptor (GLP1R) fluorescent antagonist (645/664) (CELT-112)
3nmoles vial that allows to prepare 30ml of 100nM working solution to test GLP1R. One vial is sufficient for injecting one mouse.
385,00€
Working concentration might differ among assay designs.View moreOur GLP1R fluorescent antagonist shows high affinity for GLP1 receptor (pEC50 = 7.5 for GLP1R) modulating the rece
ptor by orthosteric antagonism. The efficacy and potency of LUXendin645 (CELT-112) as a GLP1R ligand was confirmed by inhibition of GLP-1-stimulated cAMP levels in SNAP-GLP1R:HEK293 cells. LUXendin645 (CELT-112) has been used in a variety of imaging applications, including widefield/confocal/2-photon microscopy in live and fixed mammalian cells and tissue. Using TR-FRET, LUXendin645 was used in GLP1R competitive binding experiments and in GLP1R trafficking and recycling studies.
*2º Image: Widefield image of live CHO-K1:SNAP-GLP1R cells labeled with 200 nM LUXendin645. Scale bar = 40 micrometer.More information and applications
https://www.nature.com/articles/s41467-020-14309-w
https://pubmed.ncbi.nlm.nih.gov/34129856/
https://molpharm.aspetjournals.org/content/early/2021/07/27/molpharm.121.000270
https://pubs.acs.org/doi/10.1021/acsptsci.0c00022 -
LUXendin762 GLP1 receptor (GLP1R) fluorescent antagonist (762/784) (CELT-113)
3nmoles vial that allows to prepare 30ml of 100nM working solution to test GLP1R. One vial is sufficient for injecting one mouse.
385,00€
Working concentration might differ among assay designs.View moreOur GLP1R fluorescent antagonist shows high affinity for GLP1 receptor (pIC50 = 7.0 for GLP1R) modulating the receptor by orthosteric antagonism. The efficacy and potency of LUXendin762 (CELT-113) as a GLP1R ligand was confirmed by a GLP-1 stimulated cAMP levels in SNAP-GLP1R:HEK293 cells. LUXendin762 (CELT-113) has been used in a variety of imaging applications, including widefield imaging in live and fixed mammalian cells and tissue. LUXendin762 is also compatible with non-invasive fluorescence preclinical imaging.
*2º Image: Widefield image of live CHO-K1:SNAP-GLP1R cells labeled with 200 nM LUXendin762. Scale bar = 40 micrometer.
More information and applications
https://chemrxiv.org/engage/chemrxiv/article-details/60ff0d5a393cc904c94f1f18
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CELT- 174 hD2 Dopamine receptor fluorescent antagonist (589/616)
Our potent hD2 dopamine receptor fluorescent antagonist is available in a 10ug vial, allowing you to prepare 73ml of 100nM working solution to test D2R.
432,00€
Our CELT-174 product has been specifically designed to meet the needs of researchers in a variety of fields, enabling the study of D2 dopamine receptors with greater accuracy and precisionView moreOur potent and selective hD2 Dopamine receptor fluorescent antagonist shows high affinity for hD2 receptor and selectivity over the other receptor subtypes (Ki =1.06 nM for hD2 receptor in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT- 426 hD2 Dopamine receptor fluorescent antagonist (560/571)
Our CELT-426 product is available in a 10ug vial that allows you to prepare 67ml of 100nM working solution to test D2R.
432,00€
It has been specifically designed for high potency and selectivity, demonstrating a high affinity for D2 receptors and may be suitable for fluorescence-based assaysView moreOur potent and partially selective hD2 Dopamine receptor fluorescent antagonist shows high affinity for hD2 receptor and partial selectivity over the other receptor subtypes (Ki =89.3 nM for hD2 receptor in radioligand binding assay). It has been validated in Fluorescence Polarization binding assays as a valid alternative to radioligand binding assays.It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT- 419 hD3 Dopamine receptor fluorescent ligand (560/571)
Our CELT-419 product is available in a 10ug vial that allows you to prepare 74ml of 100nM working solution to test D3R.
432,00€
It has been specifically designed to target the D3 dopamine receptor, making it an ideal tool for researchers performing cell visualization in fluorescence microscopyView moreOur potent and partially selective hD3 Dopamine receptor fluorescent ligand shows high affinity for hD3 receptor and partial selectivity over the other receptor subtypes (Ki =65.6 nM for hD3 receptor in radioligand binding assay). It has been validated in Fluorescence Polarization binding assays as a valid alternative to radioligand binding assays.It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
More information and applications
https://www.frontiersin.org/articles/10.3389/fmolb.2023.1119157/full
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CELT-240 hD2/D3 Dopamine receptors fluorescent ligand (589/616)
Our CELT-240 product is available in a 10ug vial that allows you to prepare 78ml of 100nM working solution to test D2R/D3R.
432,00€
It demonstrates high potency and selectivity, making it a valuable tool for researchers interested in studying the D2 and D3 receptorsView moreOur potent hD3/D2 Dopamine receptors fluorescent ligand shows high affinity for hD2 and hD3 receptors (Ki =2.34 nM and 2.14 nM respectively in radioligand binding assays) and selectivity over D4 dopamine receptor. It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-241 hD2/D3 Dopamine receptors fluorescent ligand (646/662)
Our CELT-241 product is available in a 10ug vial that allows you to prepare 68ml of 100nM working solution to test D2R/D3R.
432,00€
It demonstrates high potency and selectivity, making it a valuable tool for researchers interested in studying D2 and D3 receptorsView moreOur potent hD2/D3 Dopamine receptors fluorescent ligand shows a high affinity for hD2 and hD3 receptors (Ki = 5.22 nM and 4.77 nM respectively in radioligand binding assays) nd selectivity over D4 dopamine receptor. It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.