Products

Published Articles

Do you want more information?

We are ready to support your challenges

Showing 1–15 of 34 results

  • CELT- 011 h5HT2A/5HT2C Serotonin receptor fluorescent antagonist (560/571)

    10ug vial that allows to prepare 80ml of 100nM working solution to test 5HT2A/5HT2C Serotonin Receptor.

    Working concentration might differ among assay designs

    432,00

    Our CELT-011 fluorescent antagonist has a high affinity for h5HT2A/h5HT2C serotonin receptors (Ki =48.8 nM and 28.8 nM, respectively in radioligand binding assay). With a 10ug vial that allows you to prepare 80ml of 100nM working solution, this product is perfect for testing 5HT2AR/5HT2CR. It enables cell visualization in fluorescence microscopy, confocal microscopy, and high-content system experiments, and it is potentially suitable for other fluorescence-based assays, such as fluorescence polarization.

    View more
  • CELT- 145 hAT1 angiotensin receptor fluorescent antagonist (646/662)

    10ug vial that allows to prepare 63ml of 100nM working solution to test AT1 Receptor.

    Working concentration might differ among assay designs

    432,00

    Our CELT-145 ligand is a highly potent fluorescent antagonist developed for hA1R  testing with a Ki of 160 nM in radioligand binding assay. The product comes in a 10ug vial that enables the preparation of 63ml of 100nM working solution to test AT1R. Our fluorescent antagonist is ideal for visualization in confocal microscopy and high-content system experiments. Our CELT-145 ligand is potentially suitable for other fluorescence-based assays such as HTRF.

    View more
  • CELT- 252 hAT1 angiotensin receptor fluorescent antagonist (560/571)

    10ug vial that allows to prepare 69ml of 100nM working solution to test AT1 Receptor.

    Working concentration might differ among assay designs

    432,00

    Our CELT-252 ligand is a highly potent fluorescent antagonist developed for hA1R  testing with a Ki of 39 nM in radioligand binding assay. The product comes in a 10ug vial that enables the preparation of 69ml of 100nM working solution to test AT1R. Our fluorescent antagonist is ideal for visualization in confocal microscopy and high-content system experiments. Our CELT-252 ligand is potentially suitable for other fluorescence-based assays such as Fluorescence Polarization.

    View more
  • CELT-150 VHL E3 ligase fluorescent ligand (646/662)

    10ug vial that allows to prepare 33mL of 200 nM working solution.

    Working concentration might differ among assay designs

    250,00

    Our potent CELT-150 VHL E3 ligase fluorescent ligand is a tracer for VHL E3 ligases binding assays, designed to perform affinity binding curves to VHL protein using TR-FRET homogenous technology.

    Von Hippel–Lindau protein (VHL) is the substrate recognition subunit of an E3 ligase recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a targeted protein.

    View more
  • CELT-249 hM1/M2 Muscarinic Receptor fluorescent antagonist (589/616)

    10ug vial that allows to prepare 82ml of 100nM working solution to test M1/M2 Muscarinic Receptor.

    Working concentration might differ among assay designs

    432,00

    Our CELT-249 ligand is a highly potent fluorescent antagonist developed for hM1R and hM2R testing with a Ki of 133 nM and 11.5 nM, respectively in radioligand binding assay. The product comes in a 10ug vial that enables the preparation of 82ml of 100nM working solution to test M1R/M2R. Our fluorescent antagonist is ideal for visualization in confocal microscopy and high-content system experiments. Our CELT-249 ligand is potentially suitable for other fluorescence-based assays

    View more
  • CELT-483 Sigma hσ1/σ2 receptor fluorescent ligand (646/662)

    10ug vial that allows to prepare 103 ml of 100nM working solution to test σ1/σ2 Receptors.

    Working concentration might differ among assay designs

    432,00

    Our potent Sigma h σ12 receptor fluorescent ligand is available in a 10ug vial, allowing you to prepare 103 ml of 100nM working solution to test σ12 receptors. Our CELT-483 product has been specifically designed to meet the needs of researchers in a variety of fields, enabling the study of σ1 and σ2 receptors with accuracy and precision. It has been validated in flow cytometry (Kd=13,59 nM for σ2) and confocal microcopy in MCF7 cell lines (see publication for more details) to study both σ1 and σreceptors, using the appropriate masking agent.

    CELT-483 with masking agents kit

    We also provide kits of CELT-483 together with potent and selective σ1 and σ2 receptors masking agents (L6 and F390, respectively).

    490,00€
    View more
  • LUXendin551 GLP1 receptor (GLP1R) fluorescent antagonist (551/576) (CELT-111)

    3nmoles vial that allows to prepare 30ml of 100nM working solution to test GLP1R. One vial is sufficient for injecting one mouse.

    Working concentration might differ among assay designs.

    385,00

    Our GLP1R fluorescent antagonist shows high affinity for GLP1 receptor (pIC50 = 7.2 for GLP1R) modulating the receptor by orthosteric antagonism.The efficacy and potency of LUXendin551 (CELT-111) as a GLP1R ligand was confirmed by inhibition of GLP-1-stimulated cAMP levels in SNAP-GLP1R:HEK293 cells. LUXendin551 (CELT-111) has been used in a variety of imaging applications, including widefield/confocal/2-photon microscopy in live and fixed mammalian cells and tissue, as well as anaesthetized mice.

    *2º Image: Widefield image of live CHO-K1:SNAP-GLP1R cells labeled with 200 nM LUXendin551. Scale bar = 40 micrometer.

    More information and applications

    https://chemrxiv.org/engage/chemrxiv/article-details/60ff0d5a393cc904c94f1f18

    View more
  • LUXendin645 GLP1 receptor (GLP1R) fluorescent antagonist (645/664) (CELT-112)

    3nmoles vial that allows to prepare 30ml of 100nM working solution to test GLP1R. One vial is sufficient for injecting one mouse.

    Working concentration might differ among assay designs.

    385,00

    Our GLP1R fluorescent antagonist shows high affinity for GLP1 receptor (pEC50 = 7.5 for GLP1R) modulating the rece
    ptor by orthosteric antagonism. The efficacy and potency of LUXendin645 (CELT-112) as a GLP1R ligand was confirmed by inhibition of GLP-1-stimulated cAMP levels in SNAP-GLP1R:HEK293 cells. LUXendin645 (CELT-112) has been used in a variety of imaging applications, including widefield/confocal/2-photon microscopy in live and fixed mammalian cells and tissue. Using TR-FRET, LUXendin645 was used in GLP1R competitive binding experiments and in GLP1R trafficking and recycling studies.
    *2º Image: Widefield image of live CHO-K1:SNAP-GLP1R cells labeled with 200 nM LUXendin645. Scale bar = 40 micrometer.

    More information and applications

    https://www.nature.com/articles/s41467-020-14309-w
    https://pubmed.ncbi.nlm.nih.gov/34129856/
    https://molpharm.aspetjournals.org/content/early/2021/07/27/molpharm.121.000270
    https://pubs.acs.org/doi/10.1021/acsptsci.0c00022

    View more
  • LUXendin762 GLP1 receptor (GLP1R) fluorescent antagonist (762/784) (CELT-113)

    3nmoles vial that allows to prepare 30ml of 100nM working solution to test GLP1R. One vial is sufficient for injecting one mouse.

    Working concentration might differ among assay designs.

    385,00

    Our GLP1R fluorescent antagonist shows high affinity for GLP1 receptor (pIC50 = 7.0 for GLP1R) modulating the receptor by orthosteric antagonism. The efficacy and potency of LUXendin762 (CELT-113) as a GLP1R ligand was confirmed by a GLP-1 stimulated cAMP levels in SNAP-GLP1R:HEK293 cells. LUXendin762 (CELT-113) has been used in a variety of imaging applications, including widefield imaging in live and fixed mammalian cells and tissue. LUXendin762 is also compatible with non-invasive fluorescence preclinical imaging.

    *2º Image: Widefield image of live CHO-K1:SNAP-GLP1R cells labeled with 200 nM LUXendin762. Scale bar = 40 micrometer.

    More information and applications

    https://chemrxiv.org/engage/chemrxiv/article-details/60ff0d5a393cc904c94f1f18

    View more
  • CELT- 174 hD2 Dopamine receptor fluorescent antagonist (589/616)

    Our potent hD2 dopamine receptor fluorescent antagonist is available in a 10ug vial, allowing you to prepare 73ml of 100nM working solution to test D2R.

    Our CELT-174 product has been specifically designed to meet the needs of researchers in a variety of fields, enabling the study of D2 dopamine receptors with greater accuracy and precision

    432,00

    Our potent and selective hD2 Dopamine receptor fluorescent antagonist shows high affinity for hD2 receptor and selectivity over the other receptor subtypes (Ki =1.06 nM for hD2 receptor in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.

    View more
  • CELT- 426 hD2 Dopamine receptor fluorescent antagonist (560/571)

    Our CELT-426 product is available in a 10ug vial that allows you to prepare 67ml of 100nM working solution to test D2R.

    It has been specifically designed for high potency and selectivity, demonstrating a high affinity for D2 receptors and may be suitable for fluorescence-based assays

    432,00

    Our potent and partially selective hD2 Dopamine receptor fluorescent antagonist shows high affinity for hD2 receptor and partial selectivity over the other receptor subtypes (Ki =89.3 nM for hD2 receptor in radioligand binding assay). It has been validated in Fluorescence Polarization binding assays as a valid alternative to radioligand binding assays.It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.

    View more
  • CELT- 419 hD3 Dopamine receptor fluorescent ligand (560/571)

    Our CELT-419 product is available in a 10ug vial that allows you to prepare 74ml of 100nM working solution to test D3R.

    It has been specifically designed to target the D3 dopamine receptor, making it an ideal tool for researchers performing cell visualization in fluorescence microscopy

    432,00

    Our potent and partially selective hD3 Dopamine receptor fluorescent ligand shows high affinity for hD3 receptor and partial selectivity over the other receptor subtypes (Ki =65.6 nM for hD3 receptor in radioligand binding assay). It has been validated in Fluorescence Polarization binding assays as a valid alternative to radioligand binding assays.It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.

    More information and applications

    https://www.frontiersin.org/articles/10.3389/fmolb.2023.1119157/full

    View more
  • CELT-240 hD2/D3 Dopamine receptors fluorescent ligand (589/616)

    Our CELT-240 product is available in a 10ug vial that allows you to prepare 78ml of 100nM working solution to test D2R/D3R.

    It demonstrates high potency and selectivity, making it a valuable tool for researchers interested in studying the D2 and D3 receptors

    432,00

    Our potent hD3/D2 Dopamine receptors fluorescent ligand shows high affinity for hD2 and hD3 receptors (Ki =2.34 nM and 2.14 nM respectively in radioligand binding assays) and selectivity over D4 dopamine receptor. It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.

    View more
  • CELT-241 hD2/D3 Dopamine receptors fluorescent ligand (646/662)

    Our CELT-241 product is available in a 10ug vial that allows you to prepare 68ml of 100nM working solution to test D2R/D3R.

    It demonstrates high potency and selectivity, making it a valuable tool for researchers interested in studying D2 and D3 receptors

    432,00

    Our potent hD2/D3 Dopamine receptors fluorescent ligand shows a high affinity for hD2 and hD3 receptors (Ki = 5.22 nM and 4.77 nM respectively in radioligand binding assays) nd selectivity over D4 dopamine receptor. It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.

    View more
  • CELT-429 hD3 Dopamine receptor fluorescent ligand (589/616)

    Our CELT-429 product is available in a 10ug vial that allows you to prepare 78ml of 100nM working solution to test D3R.

    It demonstrates high potency and selectivity, making it a valuable tool for researchers interested in studying the role of D3 receptors in various physiological and pathological conditions

    432,00

    Our potent and selective hD3 Dopamine receptors fluorescent ligand shows a high affinity for hD3 receptors (Ki = 75.4 nM in radioligand binding assays) and selectivity over D3 and D4 dopamine receptor. It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.

    View more
1 2 3