15 April 2026
dual GLP-1 GIP receptor agonists

Dual GLP-1/GIP Receptor Agonists: Mechanism of Action, Metabolic Implications, and Drug Discovery Advantages

How dual GLP-1/GIP receptor agonists like tirzepatide work, their pharmacological advantages over single agonists, and preclinical assay strategies.
30 March 2026
Measuring Receptor Binding Kinetics and Residence Time Using Fluorescent Ligands

Measuring Receptor Binding Kinetics and Residence Time Using Fluorescent Ligands in GPCR Drug Discovery

Fluorescent ligands have become powerful tools for measuring receptor binding kinetics and residence time in GPCR drug discovery. Unlike traditional radioligand approaches, fluorescence-based methods enable real-time, […]
12 March 2026
Ligand binding assays for non-GPCR drug

Ligand Binding Assays Beyond GPCRs: Techniques, Best Practices and Applications in Drug Discovery

Ligand binding assays for non-GPCR drug targets like Sigma receptors and E3 ligases.
6 February 2026
High content screening automation for GPCR

Automation in High‑content Screening for GPCR Drug Discovery: Boosting Reproducibility and Throughput

Improve reproducibility and accelerate GPCR drug discovery with automated high-content screening assays and smart data workflows.
4 February 2026
Pharmacophore Characterization with Time-Resolved Fluorescence

Enhancing Pharmacophore Characterization with Time-Resolved Fluorescence Techniques

Time-resolved fluorescence improves pharmacophore characterization accuracy in biochemical assays for advanced drug discovery workflows.
23 December 2025
HCS to overcome controlled substance barriers

Overcoming Controlled Substance Barriers in Cannabinoid Receptor Drug Discovery with High-Content Screening

How high-content screening enables cannabinoid receptor research while avoiding controlled substance restrictions and improving assay scalability.
16 December 2025
high content screening with CB2

High-Content Screening Applied to CB₂ Cannabinoid Receptor Ligand Binding

High-content screening enables precise CB2 receptor binding analysis in preclinical research using advanced imaging, quantification, and assay tools.
11 November 2025
Cell Painting in High‑Content Screening

Cell Painting in High‑Content Screening: Limitations and the Rise of Fluorescent Ligands as a Scalable Alternative

How fluorescent ligands offer a scalable, specific alternative to cell painting in high-content screening workflows.
28 October 2025
Design robust high-content screening (HCS) assays

Designing High‑Content Screening (HCS) Assays: Strategies to Overcome Limitations

How to design robust high-content screening (HCS) assays, avoid artifacts and batch effects, and improve drug discovery results.