Products
Our GPCR fluorescent ligands are the ideal solution for your High Throughput Screening (HTS) needs.
Our proprietary technology enables the synthesis of fluorescent ligands with exceptional performance features, including high potency, selectivity, and affinity. Our ligands have been designed to fill the gaps in the available tools for HTS, making the screening process faster and more efficient than ever before.
This technology has been used to study a variety of signaling pathways in drug discovery, providing an invaluable resource for researchers interested in GPCR signaling and drug discovery.
- Our ligands have a potent (Ki < 100 nM) and subtype-selective (>100-fold) feature that allows for thousands of tests in HTS assays, typically 3,000-6,000 points in 384 plates for a 10µg vial. The stable fluorophores, implemented to guarantee high affinity binding, present a variety of photo-physical properties adaptable for many different applications as Fluorescence Polarization and FRET.
- The pharmacophores of our ligands are representative of the target and are aligned with international standards, providing a reliable resource for researchers interested in G-protein-coupled receptor (GPCR) research and ligand binding. Our spacers allow optimal target recognition and placement of the fluorophore in the outer region of the cell membrane, enhancing the accuracy of the screening process.
At Celtarys, we are committed to providing you with the best products on the market for GPCR research and drug discovery, and we are constantly developing new solutions to meet your needs.
Published articles using our fluorescent probes
CELT-228 hA3 Adenosine receptor fluorescent antagonist (560/671)
CELT-335 hCB1/CB2 Cannabinoids receptors fluorescent ligand (646/662)
CELT-327 hA2B/A3 Adenosine receptor fluorescent antagonist (589/616)
LUXendin 551 glucagon-like peptide-1 receptor (GLP1R) fluorescent antagonist (551/576) (CELT-111)
LUXendin 645 glucagon-like peptide-1 receptor (GLP1R) fluorescent antagonist (645/664) (CELT-112)
LUXendin 762 glucagon-like peptide-1 receptor (GLP1R) fluorescent antagonist (762/784) (CELT-113)
CELT-419 hD3 Dopamine receptor fluorescent ligand (560/571)
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Showing 16–30 of 33 results
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CELT- 58 C5a receptor fluorescent antagonist (646/662)
10ug vial that allows to prepare 87ml of 100nM working solution to test C5aR.
432,00€
Working concentration might differ among assay designs.View moreOur potent C5a receptor fluorescent antagonist shows high affinity for the C5aR (EC50 = 24.89 nM by saturation binding in Chem1 transfected cells), good potency (KB= 5.8 μM by calcium flux assay) and good competition with the endogenous ligand C5a. It has been validated in flow cytometry competition binding assays using Chem1 transfected cells. It is potentially suitable for other fluorescence-based assays.
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CELT-130 hα1 adrenergic receptor fluorescent antagonist (646/662)
10ug vial that allows to prepare 83ml of 100nM working solution to test alpha1AR.
432,00€
Working concentration might differ among assay designs
Our CELT-130 product has been developed to meet the needs of researchers in a variety of fields, enabling the study of alpha1a adrenergic receptors with greater accuracy and precision.View moreOur potent and selective hα1A adrenergic receptor fluorescent antagonist shows high affinity for α1A adrenergic receptor (Ki =28.3 nM measured in radioligand binding assay) and selectivity over α2A (Ki =1081 nM measured in radioligand binding assay). It is potentially suitable for fluorescence-based assays such as confocal microscopy or high content screening.
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CELT-133 hα1 adrenergic receptor fluorescent antagonist (560/571)
This product is available in a 10ug vial that allows you to prepare 83ml of 100nM working solution to test alpha1AR.
432,00€
The working concentration might differ among assay designs
Our CELT-133 ligand has been specifically designed for high potency and selectivity. It has a high affinity for α1 receptors and may be suitable for fluorescence-based assays.View moreOur potent and selective hα1A adrenergic receptor fluorescent antagonist shows high affinity for alpha 1 adrenergic receptor (Ki =5 nM measured in radioligand binding assay) and selectivity over α2A (15% of displacement at 1 μM in radioligand binding assay). It is potentially suitable for fluorescence-based assays such as confocal microscopy, high content screening or fluorescence polarization.
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CELT-175 hD2 Dopamine receptor fluorescent antagonist (748/776)
Our CELT-175 product is available in a 10ug vial that allows you to prepare 63ml of 100nM working solution to test D2R.
432,00€
It has been specifically designed for high potency and selectivity, demonstrating a high affinity for D2 receptors and may be suitable for fluorescence-based assaysView moreOur potent and selective hD2 Dopamine receptor fluorescent antagonist shows high affinity for hD2 receptor and selectivity over the other receptor subtypes (Ki =3.15 nM for hD2 receptor and Ki =294.6 nM and Ki =220.3 nM for D3 and D4 receptor, respectively, in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-298 Pan Adenosine receptors fluorescent antagonist (646/662)
10ug vial that allows to prepare 74ml of 100nM working solution to test A2AR.
432,00€
Working concentration might differ among assay designsView moreOur potent Pan Adenosine receptors fluorescent antagonist shows affinity for hA1, hA2A, hA2B and hA3 Adenosine receptors (Ki =20.9 nM, 171 nM, 44,7nM and 95.2 nM respectively in radioligand binding assays). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-448 hA1 Adenosine receptor fluorescent antagonist (560/571)
10ug vial that allows to prepare 77ml of 100nM working solution to test A1R.
432,00€
Working concentration might differ among assay designsView morePotent and selective hA1 Adenosine receptors fluorescent antagonist (560/571)
Our potent and selective hA1 Adenosin receptor fluorescent antagonist shows affinity and selectivity for hA1, (Ki =26.2 nM in radioligand binding assays). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-372 hA1/hA2b Adenosine receptors fluorescent antagonist (589/616)
10ug vial that allows to prepare 86ml of 100nM working solution to test A1R/A2R.
432,00€
Working concentration might differ among assay designsView moreOur potent hA1/A2B Adenosine receptor fluorescent antagonist shows affinity for hA1and hA2B Adenosine receptors (Ki =1.89 nMand 24.65 nM respectively in radioligand binding assays), intermediate affinity for A2A (Ki=80.33 nM) and very low affinity for A3 Adenosine receptor (Ki =967.48 nM). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-360 hA1 Adenosine receptor fluorescent antagonist (646/662)
10ug vial that allows to prepare 78ml of 100nM working solution to test A1R.
432,00€
Working concentration might differ among assay designsView moreOur potent and partially selective hA1 Adenosine receptor fluorescent antagonist shows higher affinity for hA1 (Ki =8.60 nM) compared to hA2A, hA2B and hA3 Adenosine receptors (Ki= 98.38 nM, 72.24 and 231.01 nM respectively in radioligand binding assays). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-300 hA2A Adenosine receptor fluorescent ligand (646/662)
10ug vial that allows to prepare 75ml of 100nM working solution to test A2AR
View moreOur potent and selective hA2A Adenosine receptor fluorescent ligand shows high affinity and selectivity for hA2A receptor (Ki =8.35 nM for hA2A receptor in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-316 hA2A Adenosine receptor fluorescent ligand (589/616)
10ug vial that allows to prepare 87ml of 100nM working solution to test A2AR.
432,00€
Working concentration might differ among assay designsView moreOur potent and selective hA2A Adenosine receptor fluorescent ligand shows high affinity and selectivity for hA2A receptor (Ki =116.1 nM for hA2A receptor in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-327 hA2B/A3 Adenosine receptor fluorescent antagonist (589/616)
10ug vial that allows to prepare 82ml of 100nM working solution to test A3R/A2BR.
432,00€
Working concentration might differ among assay designsView moreOur potent hA2B/A3 Adenosine receptor fluorescent antagonist shows high affinity for hA2B and A3 receptor (Ki =35.6 nM and 45.7 nM respectively in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
More information and applications
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CELT-228 hA3 Adenosine receptor fluorescent antagonist (560/571)
10ug vial that allows to prepare 77ml of 100nM working solution to test A3R.
432,00€
Working concentration might differ among assay designsView moreOur potent and selective hA3 Adenosine receptor fluorescent antagonist shows high affinity for hA3 receptor and partial selectivity over the other receptor subtypes (Ki =52.7 nM for hA3 receptor in radioligand binding assay). It has been validated in Fluorescence Polarization binding assays as a valid alternative to radioligand binding assays.It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
More information and applications
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CELT- 171 hA3 Adenosine receptor fluorescent antagonist (589/616)
10ug vial that allows to prepare 86ml of 100nM working solution to test A3R.
432,00€
Working concentration might differ among assay designsView moreOur potent and selective hA3 Adenosine receptor fluorescent antagonist shows a high affinity and selectivity for hA3 receptor over the other receptor subtypes (Ki =6.13 nM for A3 receptor in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT- 402 h5HT2A/5HT2C Serotonin receptor fluorescent antagonist (589/616)
10ug vial that allows to prepare 90ml of 100nM working solution to test 5HT2AR/5HT2CR.
432,00€
Working concentration might differ among assay designsView moreOur fluorescent antagonist has a high affinity for h5HT2A/h5HT2C serotonin receptors (Ki =29.7 nM and 14.6 nM, respectively in radioligand binding assay). With a 10ug vial that allows you to prepare 200ml of 100nM working solution, this product is perfect for testing 5HT2AR/5HT2CR. It enables cell visualization in fluorescence microscopy, confocal microscopy, and high-content system experiments, and it is potentially suitable for other fluorescence-based assays.
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CELT- 211 h5HT2B Serotonin receptor fluorescent ligand (589/616)
10ug vial that allows to prepare 82ml of 100nM working solution to test 5HT2BR.
432,00€
Working concentration might differ among assay designsView moreOur potent and selective h5HT2B Serotonin receptor fluorescent ligand shows high affinity for 5HT2B serotonin receptor and high selectivity over the other receptor subtypes (Ki =56.32 nM for 5HT2B receptor in radioligand binding assay). With a 10ug vial that allows you to prepare 70ml of 100nM working solution, this product is perfect for testing 5HT2BR. It enables cell visualization in fluorescence microscopy, confocal microscopy, and high-content system experiments, and it is potentially suitable for other fluorescence-based assays.