Products
Our GPCR fluorescent ligands have been designed to fill current gaps in the available tools ready to use in HTS.
Applying our proprietary synthetic technology we can satisfy the demands of big collaborative or corporative projects that need high quantities of fluorescent ligands.
Our ligands’ value:
- Potent (Ki < 100 nM) and subtype selective ( > 100-fold). Their high affinity allows to perform thousands of test in HTS assays (typically 3.000-6.000 points in 384 plates for a 10µg vial).
- Their fluorophores are stable, guarantee their affinity and display a variety of photo-physical properties that meet the market demand for several applications from competitive binding assays to microscopy
- Their pharmacophores are representative of the target and aligned with international standards
- Their spacers allow optimal target recognition and placing of the fluorophore in the outer region of the membrane.
Published articles using our fluorescent probes
CELT-228 hA3 Adenosine receptor fluorescent antagonist (560/671)
CELT-335 hCB1/CB2 Cannabinoids receptors fluorescent ligand (646/662)
CELT-327 hA2B/A3 Adenosine receptor fluorescent antagonist (589/616)
LUXendin 551 glucagon-like peptide-1 receptor (GLP1R) fluorescent antagonist (551/576) (CELT-111)
LUXendin 645 glucagon-like peptide-1 receptor (GLP1R) fluorescent antagonist (645/664) (CELT-112)
LUXendin 762 glucagon-like peptide-1 receptor (GLP1R) fluorescent antagonist (762/784) (CELT-113)
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Showing 16–28 of 28 results
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CELT-448 hA1 Adenosine receptor fluorescent antagonist (560/571)
10ug vial that allows to prepare 150ml of 100nM working solution to test A1R.
432,00€
Working concentration might differ among assay designsView morePotent and selective hA1 Adenosine receptors fluorescent antagonist (560/571)
Our potent and selective hA1 Adenosin receptor fluorescent antagonist shows affinity and selectivity for hA1, (Ki =26.2 nM in radioligand binding assays). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-372 hA1/hA2b Adenosine receptors fluorescent antagonist (589/616)
10ug vial that allows to prepare 325ml of 100nM working solution to test A1R/A2R.
432,00€
Working concentration might differ among assay designsView moreOur potent hA1/A2B Adenosine receptor fluorescent antagonist shows affinity for hA1and hA2B Adenosine receptors (Ki =1.89 nMand 24.65 nM respectively in radioligand binding assays), intermediate affinity for A2A (Ki=80.33 nM) and very low affinity for A3 Adenosine receptor (Ki =967.48 nM). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-360 hA1 Adenosine receptor fluorescent antagonist (646/662)
10ug vial that allows to prepare 450ml of 100nM working solution to test A1R.
432,00€
Working concentration might differ among assay designsView moreOur potent and partially selective hA1 Adenosine receptor fluorescent antagonist shows higher affinity for hA1 (Ki =8.60 nM) compared to hA2A, hA2B and hA3 Adenosine receptors (Ki= 98.38 nM, 72.24 and 231.01 nM respectively in radioligand binding assays). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-300 hA2A Adenosine receptor fluorescent ligand (646/662)
View moreOur potent and selective hA2A Adenosine receptor fluorescent ligand shows high affinity and selectivity for hA2A receptor (Ki =8.35 nM for hA2A receptor in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-316 hA2A Adenosine receptor fluorescent ligand (589/616)
10ug vial that allows to prepare 37ml of 100nM working solution to test A2AR.
432,00€
Working concentration might differ among assay designsView moreOur potent and selective hA2A Adenosine receptor fluorescent ligand shows high affinity and selectivity for hA2A receptor (Ki =116.1 nM for hA2A receptor in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-327 hA2B/A3 Adenosine receptor fluorescent antagonist (589/616)
10ug vial that allows to prepare 100ml of 100nM working solution to test A3R/A2BR.
432,00€
Working concentration might differ among assay designsView moreOur potent hA2B/A3 Adenosine receptor fluorescent antagonist shows high affinity for hA2B and A3 receptor (Ki =35.6 nM and 45.7 nM respectively in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-228 hA3 Adenosine receptor fluorescent antagonist (560/571)
10ug vial that allows to prepare 70ml of 100nM working solution to test A3R.
432,00€
Working concentration might differ among assay designsView moreOur potent and selective hA3 Adenosine receptor fluorescent antagonist shows high affinity for hA3 receptor and partial selectivity over the other receptor subtypes (Ki =52.7 nM for hA3 receptor in radioligand binding assay). It has been validated in Fluorescence Polarization binding assays as a valid alternative to radioligand binding assays.It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
More information and applications
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CELT- 171 hA3 Adenosine receptor fluorescent antagonist (589/616)
10ug vial that allows to prepare 700ml of 100nM working solution to test A3R.
432,00€
Working concentration might differ among assay designsView moreOur potent and selective hA3 Adenosine receptor fluorescent antagonist shows a high affinity and selectivity for hA3 receptor over the other receptor subtypes (Ki =6.13 nM for A3 receptor in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT- 402 h5HT2A/5HT2C Serotonin receptor fluorescent antagonist (589/616)
10ug vial that allows to prepare 200ml of 100nM working solution to test 5HT2AR/5HT2CR.
432,00€
Working concentration might differ among assay designsView moreOur potent h5HT2A/5HT2C Serotonin receptor fluorescent antagonist shows a high affinity for h5HT2A/h5HT2C serotonin receptors (Ki =29.7 nM and 14.6 nM respectively in radioligand binding assay).It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT- 211 h5HT2B Serotonin receptor fluorescent ligand (589/616)
10ug vial that allows to prepare 70ml of 100nM working solution to test 5HT2BR.
432,00€
Working concentration might differ among assay designsView moreOur potent and selective h5HT2B Serotonin receptor fluorescent ligand shows a high affinity for 5HT2B serotonin receptor and high selectivity over the other receptor subtypes (Ki =56.32 nM for 5HT2B receptor in radioligand binding assay).It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-335 hCB1/CB2 Cannabinoids receptors fluorescent ligand (646/662)
10ug vial that allows to prepare 150ml of 100nM working solution to test CB1R/CB2R.
432,00€
Working concentration might differ among assay designsView moreOur potent hCB cannabinoids receptors fluorescent ligand shows high affinity for hCB1/CB2 cannabinoids receptor (Ki =44.8 nM and 7.4 nM , respectively in radioligand binding assay). It has been validated in High Content Screening assays and it is suitable also for HTRF binding assays as a valid alternative to radioligand binding assays. It allows to perform cell visualization in fluorescence microscopy and it is potentially suitable for other fluorescence-based assays.
More information and applications
https://www.sciencedirect.com/science/article/pii/S1043661821005545?via%3Dihub
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CELT-331 hCB2 Cannabinoids receptor fluorescent ligand (646/662)
View moreOur potent and selective hCB2 cannabinoids receptor fluorescent ligand shows high affinity for hCB2 cannabinoids receptor and selectivity over hCB1 (Ki =75.9 nM for hCB2 receptor in radioligand binding assay). It is suitable for HTRF binding assays as a valid alternative to radioligand binding assays. It allows to perform cell visualization in fluorescence microscopy, confocal and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-195 hM1/M2 Muscarinic receptor fluorescent antagonist (748/776)
10ug vial that allows to prepare 95ml of 100nM working solution to test M1R/M2R.
432,00€
Working concentration might differ among assay designsView moreOur potent hM1/hM2 Muscarinic receptor fluorescent antagonist shows high affinity for hM1 and hM2 Muscarinic receptors (Ki =57.77 nM and 37,7 nM respectively in radioligand binding assay). It allows to perform cell visualization in confocal microscopy and high content system experiments as a valid alternative to radioligand binding assays. It is potentially suitable for other fluorescence-based assays.