Our fluorescent ligands have been extensively validated as useful tools to visualize GPCRs in native and transfected cells, both in living cells and in cells after fixation.
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LUXendin551 GLP1 receptor (GLP1R) fluorescent antagonist (551/576) (CELT-111)
3nmoles vial that allows to prepare 30ml of 100nM working solution to test GLP1R. One vial is sufficient for injecting one mouse.
385,00€
Working concentration might differ among assay designs.View moreOur GLP1R fluorescent antagonist shows high affinity for GLP1 receptor (pIC50 = 7.2 for GLP1R) modulating the receptor by orthosteric antagonism.The efficacy and potency of LUXendin551 (CELT-111) as a GLP1R ligand was confirmed by inhibition of GLP-1-stimulated cAMP levels in SNAP-GLP1R:HEK293 cells. LUXendin551 (CELT-111) has been used in a variety of imaging applications, including widefield/confocal/2-photon microscopy in live and fixed mammalian cells and tissue, as well as anaesthetized mice.
*2º Image: Widefield image of live CHO-K1:SNAP-GLP1R cells labeled with 200 nM LUXendin551. Scale bar = 40 micrometer.
More information and applications
https://chemrxiv.org/engage/chemrxiv/article-details/60ff0d5a393cc904c94f1f18
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LUXendin645 GLP1 receptor (GLP1R) fluorescent antagonist (645/664) (CELT-112)
3nmoles vial that allows to prepare 30ml of 100nM working solution to test GLP1R. One vial is sufficient for injecting one mouse.
385,00€
Working concentration might differ among assay designs.View moreOur GLP1R fluorescent antagonist shows high affinity for GLP1 receptor (pEC50 = 7.5 for GLP1R) modulating the rece
ptor by orthosteric antagonism. The efficacy and potency of LUXendin645 (CELT-112) as a GLP1R ligand was confirmed by inhibition of GLP-1-stimulated cAMP levels in SNAP-GLP1R:HEK293 cells. LUXendin645 (CELT-112) has been used in a variety of imaging applications, including widefield/confocal/2-photon microscopy in live and fixed mammalian cells and tissue. Using TR-FRET, LUXendin645 was used in GLP1R competitive binding experiments and in GLP1R trafficking and recycling studies.
*2º Image: Widefield image of live CHO-K1:SNAP-GLP1R cells labeled with 200 nM LUXendin645. Scale bar = 40 micrometer.More information and applications
https://www.nature.com/articles/s41467-020-14309-w
https://pubmed.ncbi.nlm.nih.gov/34129856/
https://molpharm.aspetjournals.org/content/early/2021/07/27/molpharm.121.000270
https://pubs.acs.org/doi/10.1021/acsptsci.0c00022 -
LUXendin762 GLP1 receptor (GLP1R) fluorescent antagonist (762/784) (CELT-113)
3nmoles vial that allows to prepare 30ml of 100nM working solution to test GLP1R. One vial is sufficient for injecting one mouse.
385,00€
Working concentration might differ among assay designs.View moreOur GLP1R fluorescent antagonist shows high affinity for GLP1 receptor (pIC50 = 7.0 for GLP1R) modulating the receptor by orthosteric antagonism. The efficacy and potency of LUXendin762 (CELT-113) as a GLP1R ligand was confirmed by a GLP-1 stimulated cAMP levels in SNAP-GLP1R:HEK293 cells. LUXendin762 (CELT-113) has been used in a variety of imaging applications, including widefield imaging in live and fixed mammalian cells and tissue. LUXendin762 is also compatible with non-invasive fluorescence preclinical imaging.
*2º Image: Widefield image of live CHO-K1:SNAP-GLP1R cells labeled with 200 nM LUXendin762. Scale bar = 40 micrometer.
More information and applications
https://chemrxiv.org/engage/chemrxiv/article-details/60ff0d5a393cc904c94f1f18
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CELT- 174 hD2 Dopamine receptor fluorescent antagonist (589/616)
Our potent hD2 dopamine receptor fluorescent antagonist is available in a 10ug vial, allowing you to prepare 73ml of 100nM working solution to test D2R.
432,00€
Our CELT-174 product has been specifically designed to meet the needs of researchers in a variety of fields, enabling the study of D2 dopamine receptors with greater accuracy and precisionView moreOur potent and selective hD2 Dopamine receptor fluorescent antagonist shows high affinity for hD2 receptor and selectivity over the other receptor subtypes (Ki =1.06 nM for hD2 receptor in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-298 Pan Adenosine receptors fluorescent antagonist (646/662)
10ug vial that allows to prepare 74ml of 100nM working solution to test A2AR.
432,00€
Working concentration might differ among assay designsView moreOur potent Pan Adenosine receptors fluorescent antagonist shows affinity for hA1, hA2A, hA2B and hA3 Adenosine receptors (Ki =20.9 nM, 171 nM, 44,7nM and 95.2 nM respectively in radioligand binding assays). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-360 hA1 Adenosine receptor fluorescent antagonist (646/662)
10ug vial that allows to prepare 78ml of 100nM working solution to test A1R.
432,00€
Working concentration might differ among assay designsView moreOur potent and partially selective hA1 Adenosine receptor fluorescent antagonist shows higher affinity for hA1 (Ki =8.60 nM) compared to hA2A, hA2B and hA3 Adenosine receptors (Ki= 98.38 nM, 72.24 and 231.01 nM respectively in radioligand binding assays). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT-327 hA2B/A3 Adenosine receptor fluorescent antagonist (589/616)
10ug vial that allows to prepare 82ml of 100nM working solution to test A3R/A2BR.
432,00€
Working concentration might differ among assay designsView moreOur potent hA2B/A3 Adenosine receptor fluorescent antagonist shows high affinity for hA2B and A3 receptor (Ki =35.6 nM and 45.7 nM respectively in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
More information and applications
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CELT- 171 hA3 Adenosine receptor fluorescent antagonist (589/616)
10ug vial that allows to prepare 86ml of 100nM working solution to test A3R.
432,00€
Working concentration might differ among assay designsView moreOur potent and selective hA3 Adenosine receptor fluorescent antagonist shows a high affinity and selectivity for hA3 receptor over the other receptor subtypes (Ki =6.13 nM for A3 receptor in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
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CELT- 211 h5HT2B Serotonin receptor fluorescent ligand (589/616)
10ug vial that allows to prepare 82ml of 100nM working solution to test 5HT2BR.
432,00€
Working concentration might differ among assay designsView moreOur potent and selective h5HT2B Serotonin receptor fluorescent ligand shows high affinity for 5HT2B serotonin receptor and high selectivity over the other receptor subtypes (Ki =56.32 nM for 5HT2B receptor in radioligand binding assay). With a 10ug vial that allows you to prepare 70ml of 100nM working solution, this product is perfect for testing 5HT2BR. It enables cell visualization in fluorescence microscopy, confocal microscopy, and high-content system experiments, and it is potentially suitable for other fluorescence-based assays.
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CELT-335 hCB1/CB2 Cannabinoids receptors fluorescent ligand (646/662)
10ug vial that allows to prepare 73ml of 100nM working solution to test CB1R/CB2R.
432,00€
Working concentration might differ among assay designsView moreOur CELT-335 product is a potent and selective hCB1/CB2 fluorescent ligand that shows a high affinity for CB1/CB2 receptors. It has a Ki value of 44.8 nM and 7.4 nM, respectively, in radioligand binding assay. CELT-335 has been validated in high-content screening assays and is also suitable for HTRF binding assays, providing a valid alternative to radioligand binding assays. It is available in a 10ug vial that allows for the preparation of 150ml of 100nM working solution to test CB1R/CB2R. CELT-335 is designed to allow for cell visualization in fluorescence microscopy and is potentially suitable for other fluorescence-based assays.
More information and applications
https://www.sciencedirect.com/science/article/pii/S1043661821005545?via%3Dihub
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CELT-331 hCB2 Cannabinoids receptor fluorescent ligand (646/662)
View moreOur CELT-331 product is a potent and selective hCB2 fluorescent ligand that shows a high affinity for hCB2 receptors and selectivity over hCB1. It has a Ki value of 75.9 nM for hCB2 receptors in radioligand binding assay. CELT-331 is suitable for HTRF binding assays as a valid alternative to radioligand binding assays. It is available in a 10ug vial that allows for the preparation of 150ml of 100nM working solution to test CB2R. CELT-331 is designed to allow for cell visualization in fluorescence microscopy, confocal, and high-content system experiments and is potentially suitable for other fluorescence-based assays.
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If you want to know more about how to use fluorescent ligands to characterize receptors with pharmacological interest with this and other technologies, click on the button to download the article “Fluorescent ligands: A new method to label your GPCRs”