CELT-228 hA3 Adenosine receptor fluorescent antagonist (560/571)
15 July 2021
LUXendin645 GLP1 receptor (GLP1R) fluorescent antagonist (645/664) (CELT-112)
27 September 2021

LUXendin551 GLP1 receptor (GLP1R) fluorescent antagonist (551/576) (CELT-111)

3nmoles vial that allows to prepare 30ml of 100nM working solution to test GLP1R. One vial is sufficient for injecting one mouse.

Working concentration might differ among assay designs.


Our GLP1R fluorescent antagonist shows high affinity for GLP1 receptor (pIC50 = 7.2 for GLP1R) modulating the receptor by orthosteric antagonism.The efficacy and potency of LUXendin551 (CELT-111) as a GLP1R ligand was confirmed by inhibition of GLP-1-stimulated cAMP levels in SNAP-GLP1R:HEK293 cells. LUXendin551 (CELT-111) has been used in a variety of imaging applications, including widefield/confocal/2-photon microscopy in live and fixed mammalian cells and tissue, as well as anaesthetized mice.

*2º Image: Widefield image of live CHO-K1:SNAP-GLP1R cells labeled with 200 nM LUXendin551. Scale bar = 40 micrometer.

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