E3Ligase Ligands

Identifying new E3 Ubiquitin ligase ligands for new PROTACs design is a key element that can improve selective proteasomal-dependent degradation of proteins of interest involved in many pathological processes such as cancer, chronic anaemia, and ischemia.

Our fluorescent probe for VHL E3 ligase is a powerful tool both for compound screening for new E3ligase ligands and for PROTACs analysis

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  • CELT-150 VHL E3 ligase fluorescent ligand (646/662)

    10ug vial that allows to prepare 33mL of 200 nM working solution.

    Working concentration might differ among assay designs


    Our potent CELT-150 VHL E3 ligase fluorescent ligand is a tracer for VHL E3 ligases binding assays, designed to perform affinity binding curves to VHL protein using TR-FRET homogenous technology.

    Von Hippel–Lindau protein (VHL) is the substrate recognition subunit of an E3 ligase recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a targeted protein.

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