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Our potent h5HT2A/5HT2C Serotonin receptor fluorescent antagonist shows a high affinity for h5HT2A/h5HT2C serotonin receptors (Ki =29.7 nM and 14.6 nM respectively in radioligand binding assay).It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.
Our potent and selective h5HT2B Serotonin receptor fluorescent ligand shows a high affinity for 5HT2B serotonin receptor and high selectivity over the other receptor subtypes (Ki =56.32 nM for 5HT2B receptor in radioligand binding assay).It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.