CELT- 174 hD2 Dopamine receptor fluorescent antagonist (589/616)

Our potent hD2/D3 Dopamine receptors fluorescent ligand shows a high affinity for hD2 and hD3 receptors (Ki = 5.22 nM and 4.77 nM respectively in radioligand binding assays) nd selectivity over D4 dopamine receptor. It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.

Our potent and partially selective hD2 Dopamine receptor fluorescent antagonist shows high affinity for hD2 receptor and partial selectivity over the other receptor subtypes (Ki =89.3 nM for hD2 receptor in radioligand binding assay). It has been validated in Fluorescence Polarization binding assays as a valid alternative to radioligand binding assays.It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.