Products
Our GPCR fluorescent ligands are the ideal solution for your High Throughput Screening (HTS) needs.
Our proprietary technology enables the synthesis of fluorescent ligands with exceptional performance features, including high potency, selectivity, and affinity. Our ligands have been designed to fill the gaps in the available tools for HTS, making the screening process faster and more efficient than ever before.
This technology has been used to study a variety of signaling pathways in drug discovery, providing an invaluable resource for researchers interested in GPCR signaling and drug discovery.
- Our ligands have a potent (Ki < 100 nM) and subtype-selective (>100-fold) feature that allows for thousands of tests in HTS assays, typically 3,000-6,000 points in 384 plates for a 10µg vial. The stable fluorophores, implemented to guarantee high affinity binding, present a variety of photo-physical properties adaptable for many different applications as Fluorescence Polarization and FRET.
- The pharmacophores of our ligands are representative of the target and are aligned with international standards, providing a reliable resource for researchers interested in G-protein-coupled receptor (GPCR) research and ligand binding. Our spacers allow optimal target recognition and placement of the fluorophore in the outer region of the cell membrane, enhancing the accuracy of the screening process.
At Celtarys, we are committed to providing you with the best products on the market for GPCR research and drug discovery, and we are constantly developing new solutions to meet your needs.
Published articles using our fluorescent probes
CELT-228 hA3 Adenosine receptor fluorescent antagonist (560/671)
CELT-335 hCB1/CB2 Cannabinoids receptors fluorescent ligand (646/662)
CELT-327 hA2B/A3 Adenosine receptor fluorescent antagonist (589/616)
LUXendin 551 glucagon-like peptide-1 receptor (GLP1R) fluorescent antagonist (551/576) (CELT-111)
LUXendin 645 glucagon-like peptide-1 receptor (GLP1R) fluorescent antagonist (645/664) (CELT-112)
LUXendin 762 glucagon-like peptide-1 receptor (GLP1R) fluorescent antagonist (762/784) (CELT-113)
CELT-419 hD3 Dopamine receptor fluorescent ligand (560/571)
CELT-483 hσ1/σ2 receptor fluorescent ligand (646/662)
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Showing 31–34 of 34 results
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CELT- 211 h5HT2B Serotonin receptor fluorescent ligand (589/616)
10ug vial that allows to prepare 82ml of 100nM working solution to test 5HT2BR.
432,00€
Working concentration might differ among assay designsView moreOur potent and selective h5HT2B Serotonin receptor fluorescent ligand shows high affinity for 5HT2B serotonin receptor and high selectivity over the other receptor subtypes (Ki =56.32 nM for 5HT2B receptor in radioligand binding assay). With a 10ug vial that allows you to prepare 70ml of 100nM working solution, this product is perfect for testing 5HT2BR. It enables cell visualization in fluorescence microscopy, confocal microscopy, and high-content system experiments, and it is potentially suitable for other fluorescence-based assays.
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CELT-335 hCB1/CB2 Cannabinoids receptors fluorescent ligand (646/662)
10ug vial that allows to prepare 73ml of 100nM working solution to test CB1R/CB2R.
432,00€
Working concentration might differ among assay designsView moreOur CELT-335 product is a potent and selective hCB1/CB2 fluorescent ligand that shows a high affinity for CB1/CB2 receptors. It has a Ki value of 44.8 nM and 7.4 nM, respectively, in radioligand binding assay. CELT-335 has been validated in high-content screening assays and is also suitable for HTRF binding assays, providing a valid alternative to radioligand binding assays. It is available in a 10ug vial that allows for the preparation of 150ml of 100nM working solution to test CB1R/CB2R. CELT-335 is designed to allow for cell visualization in fluorescence microscopy and is potentially suitable for other fluorescence-based assays.
More information and applications
https://www.sciencedirect.com/science/article/pii/S1043661821005545?via%3Dihub
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CELT-331 hCB2 Cannabinoids receptor fluorescent ligand (646/662)
10ug vial that allows to prepare 76ml of 100nM working solution to test CB2R.
432,00€
Working concentration might differ among assay designsView moreOur CELT-331 product is a potent and selective hCB2 fluorescent ligand that shows a high affinity for hCB2 receptors and selectivity over hCB1. It has a Ki value of 75.9 nM for hCB2 receptors in radioligand binding assay. CELT-331 is suitable for HTRF binding assays as a valid alternative to radioligand binding assays. It is available in a 10ug vial that allows for the preparation of 150ml of 100nM working solution to test CB2R. CELT-331 is designed to allow for cell visualization in fluorescence microscopy, confocal, and high-content system experiments and is potentially suitable for other fluorescence-based assays.
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CELT-195 hM1/M2 Muscarinic receptor fluorescent antagonist (748/776)
10ug vial that allows to prepare 73ml of 100nM working solution to test M1R/M2R.
432,00€
Working concentration might differ among assay designsView moreOur CELT-195 ligand is a highly potent fluorescent antagonist developed for M1R and M2R testing with a Ki of 57.77 nM and 37.7 nM, respectively in radioligand binding assay. The product comes in a 10ug vial that enables the preparation of 95ml of 100nM working solution to test M1R/M2R. Our fluorescent antagonist is ideal for visualization in confocal microscopy and high-content system experiments. Our CELT-195 ligand is potentially suitable for other fluorescence-based assays.