GLP1 receptor (GLP1R)

Our GLP1R fluorescent ligands have been tested extensively in a range of cell lines and have been found to be highly specific for the GLP-1 receptor. They are ideal for studying the GLP1 receptor in various contexts, including the study of type 2 diabetes, weight loss, and kidney disease. As a market leader in fluorescent ligand development, we are uniquely positioned to supply high-quality GLP1R solutions with high affinity for the GLP-1 receptor, making them ideal for various applications, including live cell imaging, receptor activation assays, and more.

LUXendins have been developed by Johannes Broichhagen (Max Planck Institute for Medical Research, Heidelberg, Germany and Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany) and David J. Hodson (University of Birmingham), and are exclusively licensed to Celtarys for commercialization. These ligands have been shown to be highly effective in studying the GLP-1 receptor and related proteins, including glucagon-like peptide and GLP-1 receptor agonists. The ligands are also highly effective in studying the nervous system, blood sugar levels, and cell surface signaling pathways. They have been shown to be highly effective in binding to the receptor, activating it, and studying its downstream effects.

At Celtarys, we are committed to providing you with the best products on the market for studying G protein-coupled receptors, and we are constantly developing new solutions to meet your needs.

Showing all 3 results

  • LUXendin551 GLP1 receptor (GLP1R) fluorescent antagonist (551/576) (CELT-111)

    3nmoles vial that allows to prepare 30ml of 100nM working solution to test GLP1R. One vial is sufficient for injecting one mouse.

    Working concentration might differ among assay designs.

    385,00

    Our GLP1R fluorescent antagonist shows high affinity for GLP1 receptor (pIC50 = 7.2 for GLP1R) modulating the receptor by orthosteric antagonism.The efficacy and potency of LUXendin551 (CELT-111) as a GLP1R ligand was confirmed by inhibition of GLP-1-stimulated cAMP levels in SNAP-GLP1R:HEK293 cells. LUXendin551 (CELT-111) has been used in a variety of imaging applications, including widefield/confocal/2-photon microscopy in live and fixed mammalian cells and tissue, as well as anaesthetized mice.

    *2º Image: Widefield image of live CHO-K1:SNAP-GLP1R cells labeled with 200 nM LUXendin551. Scale bar = 40 micrometer.

    More information and applications

    https://chemrxiv.org/engage/chemrxiv/article-details/60ff0d5a393cc904c94f1f18

    View more
  • LUXendin645 GLP1 receptor (GLP1R) fluorescent antagonist (645/664) (CELT-112)

    3nmoles vial that allows to prepare 30ml of 100nM working solution to test GLP1R. One vial is sufficient for injecting one mouse.

    Working concentration might differ among assay designs.

    385,00

    Our GLP1R fluorescent antagonist shows high affinity for GLP1 receptor (pEC50 = 7.5 for GLP1R) modulating the rece
    ptor by orthosteric antagonism. The efficacy and potency of LUXendin645 (CELT-112) as a GLP1R ligand was confirmed by inhibition of GLP-1-stimulated cAMP levels in SNAP-GLP1R:HEK293 cells. LUXendin645 (CELT-112) has been used in a variety of imaging applications, including widefield/confocal/2-photon microscopy in live and fixed mammalian cells and tissue. Using TR-FRET, LUXendin645 was used in GLP1R competitive binding experiments and in GLP1R trafficking and recycling studies.
    *2º Image: Widefield image of live CHO-K1:SNAP-GLP1R cells labeled with 200 nM LUXendin645. Scale bar = 40 micrometer.

    More information and applications

    https://www.nature.com/articles/s41467-020-14309-w
    https://pubmed.ncbi.nlm.nih.gov/34129856/
    https://molpharm.aspetjournals.org/content/early/2021/07/27/molpharm.121.000270
    https://pubs.acs.org/doi/10.1021/acsptsci.0c00022

    View more
  • LUXendin762 GLP1 receptor (GLP1R) fluorescent antagonist (762/784) (CELT-113)

    3nmoles vial that allows to prepare 30ml of 100nM working solution to test GLP1R. One vial is sufficient for injecting one mouse.

    Working concentration might differ among assay designs.

    385,00

    Our GLP1R fluorescent antagonist shows high affinity for GLP1 receptor (pIC50 = 7.0 for GLP1R) modulating the receptor by orthosteric antagonism. The efficacy and potency of LUXendin762 (CELT-113) as a GLP1R ligand was confirmed by a GLP-1 stimulated cAMP levels in SNAP-GLP1R:HEK293 cells. LUXendin762 (CELT-113) has been used in a variety of imaging applications, including widefield imaging in live and fixed mammalian cells and tissue. LUXendin762 is also compatible with non-invasive fluorescence preclinical imaging.

    *2º Image: Widefield image of live CHO-K1:SNAP-GLP1R cells labeled with 200 nM LUXendin762. Scale bar = 40 micrometer.

    More information and applications

    https://chemrxiv.org/engage/chemrxiv/article-details/60ff0d5a393cc904c94f1f18

    View more