CELT-360 hA1 Adenosine receptor fluorescent antagonist (646/662)

Our potent and selective hA3 Adenosine receptor fluorescent antagonist shows a high affinity and selectivity for hA3 receptor over the other receptor subtypes (Ki =6.13 nM for A3 receptor in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.

Our potent hA1/A2B Adenosine receptor fluorescent antagonist shows affinity for hA1and hA2B Adenosine receptors (Ki =1.89 nMand 24.65 nM respectively in radioligand binding assays), intermediate affinity for A2A (Ki=80.33 nM) and very low affinity for A3 Adenosine receptor (Ki =967.48 nM). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.