Custom synthesis service for fluorescent ligands
Celtarys provides custom chemical development services, specifically for the identification of a broad range of robust and complex fluorescent ligands not commercially available for the majority of therapeutic targets.
Thanks to our LEGO-like chemical conjugation technology, we can offer a portfolio of custom development extremely varied of polyfunctional fluorescent ligands.
Fluorescent ligands are composed of a pharmacophore, that specifically recognizes the target, and a fluorophore, connected by a linker. The linker has a significant influence on the biological activity of such conjugates and its nature and length play a critical role in the physicochemical properties and bioactivity of the whole final conjugate.
Thanks to our proprietary patented synthetic technology named LEGO-like chemical conjugation, we can develop tailor-made fluorescent ligands for any target of interest. Our semi-combinatorial technology allows us to design hundreds of different chemical linkers architectures, accelerating the development process and improving synthesis outcomes.
Moreover, most of the fluorophore chemical classes are compatible with our synthetic strategy thus allowing to spread of the applicability of the optimized fluorescent ligands in different assays (Fluorescence Polarization, HTRF, High Content Screening, confocal imaging, flow cytometry…).
We start with the identification of the appropriate pharmacophore(s) for each target, using an integrated approach that includes both structure-based and ligand-based drug design approaches for compound functionalization. Thanks to in-silico experimental structure-activity study we identify the optimal position for pharmacophore functionalization and linker conjugation. The optimal pharmacophore(s) are typically identified among a set of 3-5 different chemical scaffolds.
HOW TO START A PROJECT WITH US?
Are you interested to explore our custom development services for a fluorescent ligand of your interest?
Let us know some more detail about your project, by answering the following questions: