Science Highlights

30 June 2025
GPCR Target Identification in Drug Discovery with Fluorescent Ligands

Accelerating GPCR Target Identification in Drug Discovery with Fluorescent Ligands

GPCR and drug discovery: how fluorescent ligands streamline target identification for faster, more accurate screening.
6 June 2025
time resolved fluorescence applications in GPCR research

Optimizing HTRF Assays with Fluorescent Ligands: A Guide for Time-Resolved Fluorescence in GPCR Research

What is Homogeneous Time-Resolved Fluorescence (HTRF)?  Homogeneous Time-Resolved Fluorescence (HTRF) is a hybrid detection technology that combines Förster Resonance Energy Transfer (FRET) with time-resolved measurement. In […]
30 May 2025
Fluorescent Ligands into Flow Cytometry

Integrating Fluorescent Ligands into Flow Cytometry: Enhancing GPCR Analysis Beyond Traditional Antibody Staining

Flow cytometry is a laser-based method used to examine multiple physical and chemical parameters of single cells suspended in a fluid. By measuring how these particles […]
7 May 2025
Applications of Fluorescent Probes in Confocal GPCR imaging: guide for researchers

Applications of Fluorescent Probes in Confocal Imaging of GPCRs: From Live to Fixed Cells

G protein-coupled receptors (GPCRs) are pivotal in transmitting signals across cell membranes, making them essential targets in biomedical research and drug development. Confocal fluorescence microscopy imaging […]
23 April 2025
Förster Resonance Energy Transfer (FRET): A Powerful Tool for Fluorescent Probe-Based Live-Cell Imaging

Förster Resonance Energy Transfer (FRET): A Powerful Tool for Fluorescent Probe-Based Live-Cell Imaging

What Is Förster Resonance Energy Transfer (FRET) and How Does It Work? Förster Resonance Energy Transfer, or Fluorescence Resonance Energy Transfer (FRET), is a non-radiative, distance-dependent […]
9 April 2025
Fluorescent Probes for High-Throughput Screening in Drug Discovery

Fluorescent Probes for High-Throughput Screening: A Cost-Effective Alternative to Radioligands in Preclinical Research

What Is High-Throughput Screening? High-throughput screening (HTS) is a starting point to discover a new drug candidate. This method is used primarily in the early stages […]
27 March 2025
Fluorescent Ligands in Fluorescence Polarization Assays

Fluorescent Ligands in Fluorescence Polarization Assays: A Game-Changer for GPCR Drug Discovery

The development of new therapeutics depends on the ability to identify compounds that interact with specific molecular targets involved in disease pathways. Target-based screening has become […]
4 March 2025
Advantages of fluorescent probes in GPCR assays

Advantages of Fluorescent Probes in GPCR Assays

The field of drug discovery faces a critical challenge: despite their vast therapeutic potential, many G Protein-Coupled Receptors (GPCRs) remain unexplored. These receptors play a fundamental […]
21 February 2025
radioligands vs fluorescent ligands

Radioligands vs. Fluorescent Ligands: Binding Assays

Studying receptor-ligand interaction is a crucial approach in drug discovery and biomedical research. Radioligands have been the gold standard for binding assays since their first use […]