Science Highlights

11 August 2026

PROTAC Hook Effect: How E3 Ligase and Target Protein Binding Affinity Shapes Degradation Efficiency

The PROTAC hook effect limits degrader potency at high concentrations. See how E3 ligase and target protein binding affinities shape degradation outcomes.

8 July 2026

VHL, CRBN, and Emerging Ligases like DCAF: Selecting E3 Ligase Handles for PROTAC Drug Discovery

VHL, CRBN and emerging E3 ligases like DCAF: compare handles for your PROTAC program and run fluorescence-based binding assays with ready-to-use kits.

25 May 2026

Fluorescence Polarization Binding Assays for E3 Ligases in Targeted Protein Degradation (TPD) Programs

Targeted protein degradation (TPD) has reshaped drug discovery by eliminating disease-driving proteins through the cell’s own degradation systems, rather than merely blocking their activity. PROTACs (bifunctional […]

15 April 2026

Dual GLP-1/GIP Receptor Agonists: Mechanism of Action, Metabolic Implications, and Drug Discovery Advantages

How dual GLP-1/GIP receptor agonists like tirzepatide work, their pharmacological advantages over single agonists, and preclinical assay strategies.

30 March 2026

Measuring Receptor Binding Kinetics and Residence Time Using Fluorescent Ligands in GPCR Drug Discovery

Fluorescent ligands have become powerful tools for measuring receptor binding kinetics and residence time in GPCR drug discovery. Unlike traditional radioligand approaches, fluorescence-based methods enable real-time, […]

12 March 2026