Sigma (σ) receptor subtypes, σ1 and σ2, are important pharmaceutical targets for diseases like Alzheimer's, Huntington's, neuropathic pain, and cancer. Despite significant interest, there is a lack of commercial tools to study them.

To address this, Celtarys has partnered with the University “Aldo Moro” of Bari to commercialize CELT-483, a fluorescent ligand that binds to both σ1 and σ2 receptors, developed by research group of Prof. Carmen Abate. CELT-483 has been validated in various fluorescence assays (like flow cytometry and confocal microscopy), and Celtarys also offers kits with selective masking agents for σ1 and σ2 receptors.

  • Representative confocal microscopy images showing the co-localization of Compound 19 (CELT-483) with σ2 receptor expression in MCF7 cells. Cells were preincubated with 10 μM selective σ1 receptor agonist (+)-pentazocine for 2 h to mask residual σ1 receptor expression. This was followed by incubation for 1 h with the indicated fluorescent ligand at 5 μM. Then cells were fixed with paraformaldehyde, stained for σ2 receptor expression (TMEM97 ab) as well as nuclei (by DAPI), and analyzed by confocal microscopy. The ligand is colored red (scale bar of 20 μm).

    CELT-483 sigma hσ1/σ2 receptors fluorescent ligand (646/662)
    For research use only

    10 µg vial can be used to prepare 95.03 µL of a 100 µM stock solution, providing enough volume for 9 assays at a working concentration of 100 nM.

    Please note that the required concentration may vary depending on the specific assay design.

    476,00€

    Product on backorder. Contact us at info@celtarys.com for an estimated delivery date.

    View more
  • Representative confocal microscopy images showing the co-localization of Compound 19 (CELT-483) with σ2 receptor expression in MCF7 cells. Cells were preincubated with 10 μM selective σ1 receptor agonist (+)-pentazocine for 2 h to mask residual σ1 receptor expression. This was followed by incubation for 1 h with the indicated fluorescent ligand at 5 μM. Then cells were fixed with paraformaldehyde, stained for σ2 receptor expression (TMEM97 ab) as well as nuclei (by DAPI), and analyzed by confocal microscopy. The ligand is colored red (scale bar of 20 μm).

    BOX OFFER – CELT-483 with masking agents
    For research use only

    10 µg vial can be used to prepare 95.03 µL of a 100 µM stock solution, providing enough volume for 9 assays at a working concentration of 100 nM.

    Please note that the required concentration may vary depending on the specific assay design.

    539,00€

    Product on backorder. Contact us at info@celtarys.com for an estimated delivery date.

    View more

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