E3 LIGASE

11 August 2026

PROTAC Hook Effect: How E3 Ligase and Target Protein Binding Affinity Shapes Degradation Efficiency

The PROTAC hook effect limits degrader potency at high concentrations. See how E3 ligase and target protein binding affinities shape degradation outcomes.

19 July 2023

Celtarys extends its chemical conjugation technology to the development of new fluorescent ligands for E3 Ubiquitin ligases

Traditional pharmacological mechanisms leave a significant part of the genome ‘undruggable’, due to the inability to induce or block their activity using agonists and antagonists. Thanks […]

Founded projects

PERTE SALUD Proyecto Nº: IDI-2025-0751

Título: TERAPIAS AVANZADAS EN INMUNOONCOLOGÍA: UNA ESTRATEGIA INNOVADORA

BASADA EN LA DEGRADACIÓN DIRIGIDA DE GPCR EN EL EJE ADENOSINÉRGICOS

EIC Pathfinder; Project name: Unisens; Universal GPCR Activity Sensor for Next Generation Drug Discovery

Esta entidad fue beneficiaria de las ayudas para la ejecución de acciones de promoción exterior de las empresas gallegas. El objetivo principal de estas ayudas es incentivar la realización de acciones de promoción exterior generadoras de ventajas competitivas. El resultado que se pretende conseguir es el impulso de las pymes y sus productos y servicios, aumentando el número de empresas de base exportadora.

Celtarys Research is beneficiary of a WomenTechEU grant supporting deep-tech start-ups led by women

Principia 2021 Program
Celtarys staff has been funded by the Xunta de Galicia within the framework of the PRINCIPIA 2021 Program of the Galician Innovation Agency (GAIN)

InnovaPEME Program
Celtarys Innovation Plan has been funded by the InnovaPEME 2022 program of the Galician Innovation Agency (GAIN)

Bonos de Innovación de Celtarys Research (026)
Para promover o desenvolvemento tecnolóxico, a innovación e unha investigación de calidade. Esta operación está financiada pola Xunta de Galicia, a través de axudas concedidas pola Axencia Galega de Innovación, dentro do programa de axudas a empresa Bonos de innovación 2022.

Celtarys Research is part of the public-private consortium developing the project PREDICTEAM

New prognostic quantitative biomarker assays for predicting patient response to immune checkpoint inhibitor (ICI) treatment

NEOTEC · CDTI — Ministerio de Ciencia e Innovación

The Project ‘New chemical conjugation technology for therapeutic targets’ has been founded by CDTI under its program NEOTEC. The NEOTEC program objective is supporting the establishment and consolidation of technology-based enterprises. A technology-based company (EBT) is a company whose activity focuses on the exploitation of products or services that require the use of technologies and knowledge developed since the research activity. The EBT base their business strategy or activity in the intensive domain of scientific and technical knowledge. Budget awarded: 416.177€ | Execution dates: 1/1/2023 – 31/03/2024

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