Functional activity data of GPCRs (G protein-coupled receptors) are crucial in drug discovery programs for monitoring therapeutic effects and potential off-target side effects. A reliable and efficient assay for this purpose uses the non-hydrolysable GTP derivative, GTPγS, which enables the detection of G protein activation upon ligand binding. Fluorescent GTPγS offers a significant advantage over radioactive [³⁵S]GTPγS by providing the same sensitivity and robustness while allowing assays to be conducted using conventional lab equipment.
In collaboration with ArcoScreen, Celtarys developed two fluorescent GTPγS (CELT-503 and CELT-505), which emit in the red and green region, respectively, of the spectrum. These fluorescent probes have been validated by ArcoScreen on its GPCR functional screening platform, providing a reliable tool for GPCR-related research and drug discovery.
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CELT-505 fluorescent GTPγS – Green Emission Spectrum (503/509)
For research use only50 µg vial can be used to prepare 43.47 µL of a 1 mM stock solution, providing enough volume for 40 assays at a working concentration of 100 nM.
Please note that the required concentration may vary depending on the specific assay design.
219,00€View moreProduct on backorder. Contact us at info@celtarys.com for an estimated delivery date.
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CELT-503 fluorescent GTPγS – Red Emission Spectrum (589/616)
For research use only50 µg vial can be used to prepare 38.97 µL of a 1 mM stock solution, providing enough volume for 38 assays at a working concentration of 100 nM.
Please note that the required concentration may vary depending on the specific assay design.
219,00€View moreProduct on backorder. Contact us at info@celtarys.com for an estimated delivery date.
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