CELT-372 hA1/hA2b Adenosine receptors fluorescent antagonist (589/616)

Our potent and selective hA3 Adenosine receptor fluorescent antagonist shows high affinity for hA3 receptor and partial selectivity over the other receptor subtypes (Ki =52.7 nM for hA3 receptor in radioligand binding assay). It has been validated in Fluorescence Polarization binding assays as a valid alternative to radioligand binding assays.It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.

More information and applications

https://pubs.acs.org/doi/10.1021/acsmedchemlett.1c00598

Our potent Pan Adenosine receptors fluorescent antagonist shows affinity for hA1, hA2A, hA2B and hA3 Adenosine receptors (Ki =20.9 nM, 171 nM, 44,7nM and 95.2 nM respectively in radioligand binding assays). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.