Discover Our New Fluorescent Ligands For Adrenergic Receptor

Celtarys Research, sponsor of the XIV Meeting of the Spanish Drug Discovery Network
9 November 2022

Our portfolio of #GPCR#fluorescent ligands is growing
We have just added to our catalogue two more fluorescent ligands for the α1-Adrenergic receptor, CELT-130 and CELT-133.

α1-Adrenergic receptors play a vital role in the regulation of the sympathetic nervous system along with β and α2-AR family members. While all of the adrenergic receptors bind with similar affinity to the catecholamines, they can regulate different physiologies and pathophysiologies in the body because they couple to different G-proteins and signal transduction pathways.

α1-Adrenergic receptors have long been known to regulate blood pressure, smooth muscle contraction and cardiac hypertrophy. α1-AR subtypes display differences in internalization, resulting in spatio-temporal changes in signalling. Some of these processes have not still yet been characterized mainly for the lack of a trustable regents source.

Our new fluorescent α1-Adrenergic receptor ligands show high affinity for α1A adrenergic receptor and selectivity over α2A.

If you want to know more about our fluorescent ligands, do not hesitate to contact us at