Our GPCR fluorescent ligands are the ideal solution for your High Throughput Screening (HTS) needs.
Our proprietary technology enables the synthesis of fluorescent ligands with exceptional performance features, including high potency, selectivity, and affinity. Our ligands have been designed to fill the gaps in the available tools for HTS, making the screening process faster and more efficient than ever before.
This technology has been used to study a variety of signaling pathways in drug discovery, providing an invaluable resource for researchers interested in GPCR signaling and drug discovery.
- Our ligands have a potent (Ki < 100 nM) and subtype-selective (>100-fold) feature that allows for thousands of tests in HTS assays, typically 3,000-6,000 points in 384 plates for a 10µg vial. The stable fluorophores, implemented to guarantee high affinity binding, present a variety of photo-physical properties adaptable for many different applications as Fluorescence Polarization and FRET.
- The pharmacophores of our ligands are representative of the target and are aligned with international standards, providing a reliable resource for researchers interested in G-protein-coupled receptor (GPCR) research and ligand binding. Our spacers allow optimal target recognition and placement of the fluorophore in the outer region of the cell membrane, enhancing the accuracy of the screening process.
At Celtarys, we are committed to providing you with the best products on the market for GPCR research and drug discovery, and we are constantly developing new solutions to meet your needs.
Published articles using our fluorescent probes
CELT-228 hA3 Adenosine receptor fluorescent antagonist (560/671)
CELT-335 hCB1/CB2 Cannabinoids receptors fluorescent ligand (646/662)
CELT-327 hA2B/A3 Adenosine receptor fluorescent antagonist (589/616)
LUXendin 551 glucagon-like peptide-1 receptor (GLP1R) fluorescent antagonist (551/576) (CELT-111)
LUXendin 645 glucagon-like peptide-1 receptor (GLP1R) fluorescent antagonist (645/664) (CELT-112)
LUXendin 762 glucagon-like peptide-1 receptor (GLP1R) fluorescent antagonist (762/784) (CELT-113)
CELT-419 hD3 Dopamine receptor fluorescent ligand (560/571)
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