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A) Following labelling of live islets, daLUXendin660 can be fixed using either 2% or 4% formalin (FA) for 15 min (n = at least five islets from three mice). B) daLUXendin544 labels insulin-positive (INS+) cells throughout the mouse islet (n = 44 islets from five mice).
C, D) daLUXendin544 labels glucagonpositive (GCG+) and somatostatin-positive (SST+) cells throughout the islet, although to a lesser extent than INS+ cells (INS, 44 islets from five mice; GCG, 25 islets from seven mice; SST, 29 islets from seven mice).

Our GLP1R/GIPR fluorescent dual agonist shows high affinity for both GLP1 and GIP receptors modulating the receptor by orthosteric agonism.

The efficacy and potency of daLUXendin554+ (CELT-118) as a GLP1R/GIPR dual ligand was confirmed by stimulated cAMP levels in h/mGIPR and h/mGLP1R transfected HEK293 cells.

daLUXendin554+ (CELT-118) has been used in a variety of imaging applications, including widefield/confocal/2-photon microscopy in live and fixed mammalian cells and tissue.

 

daLUXendin544+ GLP1R/GIPR fluorescent agonist (561/569) (CELT-118)
For research use only

3 nmol vial that allows to prepare 30 µL of 100 µM stock solution to test GLP1R/GIPR. One vial is sufficient for injecting one mouse.

Please note that the required concentration may vary depending on the specific assay design.

525,00€

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More information and contact in info@celtarys.com

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