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CELT-327 hA2B/A3 adenosine receptor fluorescent antagonist (589/616) For research use only

HEK cells expressing the human A2B receptor labelled with (A) 72 nM CELT-327, (B) 36 nM CELT-327 and (C) 18 nM CELT-327. Competition binding assay with HEK cells expressing the human A2B receptor labelled with (D) 72 nM CELT-327 and Hoechst 33342, (E) 72 nM CELT-327 and Hoechst 33342 preincubated with 10 µM ZM241385 and (F) Hoechst 33342.

Real-time dynamic labelling of A2BAR. A) Representative confocal images of HCT116 cells pre-stained with CellTracker Green (lower panels) and labelled in real-time with 250 nM CELT-327, added at timepoint 0 (upper panels). Scale bars: 50 µm. B) Orthogonal projections on a selected area of images in A. Scale bar: 20 µm. C) Quantification of CELT-327 average fluorescence intensity over time.

Our potent hA_2B/A₃ adenosine receptor fluorescent antagonist shows high affinity for hA_2B and A₃ receptor (K_i = 35.6 nM and 45.7 nM respectively in radioligand binding assay). It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.

More information and applications

Article: Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR ligands

CELT-327 hA2B/A3 adenosine receptor fluorescent antagonist (589/616)
_{For research use only}

Name: CELT-327 hA2B/A3 adenosine receptor fluorescent antagonist (589/616) For research use only - Celtarys
Price: 476.00 EUR
Availability: InStock

10 µg vial can be used to prepare 74.95 µL of a 100 µM stock solution, providing enough volume for 7 assays at a working concentration of 100 nM.
Please note that the required concentration may vary depending on the specific assay design.

476,00€

In stock

Category: Adenosine Receptors

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More information and contact in info@celtarys.com

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More information and applications

CELT-327 hA2B/A3 adenosine receptor fluorescent antagonist (589/616) For research use only

10 µg vial can be used to prepare 74.95 µL of a 100 µM stock solution, providing enough volume for 7 assays at a working concentration of 100 nM.Please note that the required concentration may vary depending on the specific assay design.

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10 µg vial can be used to prepare 74.95 µL of a 100 µM stock solution, providing enough volume for 7 assays at a working concentration of 100 nM.
Please note that the required concentration may vary depending on the specific assay design.

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Please note that the required concentration may vary depending on the specific assay design.

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10 µg vial can be used to prepare 77.25 µL of a 100 µM stock solution, providing enough volume for 7 assays at a working concentration of 100 nM.
Please note that the required concentration may vary depending on the specific assay design.

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10 µg vial can be used to prepare 85.68 µL of a 100 µM stock solution, providing enough volume for 8 assays at a working concentration of 100 nM.
Please note that the required concentration may vary depending on the specific assay design.