New article showcasing Celtarys fluorescent ligand for Dopamine D3 Receptor in Fluorescence based HTS
Celtarys Research collaborates with several research groups in Europe for the validation of our products in different assays commonly used in drug discovery, always with the aim of showing our customers and collaborators the high versatility of our products for different applications.
In the frame of these collaborations, we have published a joint article with Professor Ago Rinken group, from the University of Tartu, Estonia. Dr. Rinken and colleagues have used our fluorescent ligand for the Dopamine D3 receptor, CELT-419, to develop receptor-ligand binding assays using fluorescence polarization and quantitative live cell epifluorescence microscopy. Notably, they have successfully tuned the fluorescence polarization assay in 384-well plates achieving Z’ value of 0.71, which is suitable for high-throughput screening of ligand binding. The paper also shows how our fluorescent probe CELT-419 can be used to determine the kinetics of Dopamine D3 receptor binding compounds or to analyze cellular distribution in live cells.
In summary, the article shows CELT-419 as a high-affinity ligand with good kinetic properties suitable both for fundamental D3 receptor-ligand binding studies and for drug screening purposes. See full article here: https://www.frontiersin.org/articles/10.3389/fmolb.2023.1119157/full
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Celtarys Research is beneficiary of a WomenTechEU grant supporting deep-tech start-ups led by women
Principia 2021 Program
Celtarys staff has been funded by the Xunta de Galicia within the framework of the PRINCIPIA 2021 Program of the Galician Innovation Agency (GAIN)
InnovaPEME Program
Celtarys Innovation Plan has been funded by the InnovaPEME 2022 program of the Galician Innovation Agency (GAIN)
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Para promover o desenvolvemento tecnolóxico, a innovación e unha investigación de calidade. Esta operación está financiada pola Xunta de Galicia, a través de axudas concedidas pola Axencia Galega de Innovación, dentro do programa de axudas a empresa Bonos de innovación 2022.
Celtarys Research is part of the public-private consortium developing the project PREDICTEAM
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The Project ‘New chemical conjugation technology for therapeutic targets’ has been founded by CDTI under its program NEOTEC. The NEOTEC program objective is supporting the establishment and consolidation of technology-based enterprises. A technology-based company (EBT) is a company whose activity focuses on the exploitation of products or services that require the use of technologies and knowledge developed since the research activity. The EBT base their business strategy or activity in the intensive domain of scientific and technical knowledge. Budget awarded: 416.177€ | Execution dates: 1/1/2023 – 31/03/2024